The bottom two in Group A meet on Thursday with both in need of a win to strengthen their qualification prospects.
The teams will meet at the Arena Pantanal in Cuiabá at 21:00 GMT.
Bolivia are bottom with no points from their first two games while Uruguay are only slightly better off with the single point they picked up in their draw against Chile. Both teams need three points from this game.
"If we want to achieve things, we have to take a step or two forward in this game," Bolivia's Venezuelan manager César Farís explained. He also confirmed the side will welcome back talismanic striker and all-time leading scorer Marcelo Moreno.
Meanwhile 'maestro' Óscar Tabárez confirmed they are going out to get the win that "puts us in a better situation despite the fact we still need to play our fourth game. For this reason, we see this game as a final".
- Details -
Stadium: Arena Pantanal (Cuiabá)
Time: 17:00 local - 21:00 - GMT
Referee: Alexis Herrera (VEN)
- History -
- Uruguay has only lost one of their last 12 games against Bolivia in all competitions (8 wins, 3 draws). The defeat came in 2014 World Cup in La Paz with Bolivia picking up a 1-0 win.
- Uruguay has won 11 of the 13 games against Bolivia on neutral ground (1 draw, 1 loss). Bolivia's only win came back in 1949 with a 3-2 triump in Rio de Janeiro at the CONMEBOL Copa América.
- Bolivia are looking to end a streak of five consecutive defeats and ten games without a win at the CONMEBOL Copa America in Brazil (2 draws, 8 losses). They have only ever won four games in this competition in Brazil, all in 1949.
- Bolivia is the team in this CONMEBOL Copa America with the lowest average ball possession (31.2%) and the one with the highest percentage of passes to the attack (39.4% of their total passes).
